751 research outputs found
The Application of Mossbauer Spectroscopy to the Study of Corrosion
The Mossbauer spectroscopic methods that have been used for
studying corrosion phenomena include transmission, emission and
reflection (scatterimg) techniques. Each of these techniques provides
unique capabilities for studying a wide range of applied and
fundamental corrosion problems. The various Mossbauer spectroscopic
techniques are described and compared, and applications of
each method to corrosion studies are reviewed
Critical Phenomena in Neutron Stars I: Linearly Unstable Nonrotating Models
We consider the evolution in full general relativity of a family of linearly
unstable isolated spherical neutron stars under the effects of very small,
perturbations as induced by the truncation error. Using a simple ideal-fluid
equation of state we find that this system exhibits a type-I critical
behaviour, thus confirming the conclusions reached by Liebling et al. [1] for
rotating magnetized stars. Exploiting the relative simplicity of our system, we
are able carry out a more in-depth study providing solid evidences of the
criticality of this phenomenon and also to give a simple interpretation of the
putative critical solution as a spherical solution with the unstable mode being
the fundamental F-mode. Hence for any choice of the polytropic constant, the
critical solution will distinguish the set of subcritical models migrating to
the stable branch of the models of equilibrium from the set of subcritical
models collapsing to a black hole. Finally, we study how the dynamics changes
when the numerically perturbation is replaced by a finite-size, resolution
independent velocity perturbation and show that in such cases a nearly-critical
solution can be changed into either a sub or supercritical. The work reported
here also lays the basis for the analysis carried in a companion paper, where
the critical behaviour in the the head-on collision of two neutron stars is
instead considered [2].Comment: 15 pages, 9 figure
Use of Most Bothersome Symptom as a Coprimary Endpoint in Migraine Clinical Trials: A Post-Hoc Analysis of the Pivotal ZOTRIP Randomized, Controlled Trial.
ObjectiveTo better understand the utility of using pain freedom and most bothersome headache-associated symptom (MBS) freedom as co-primary endpoints in clinical trials of acute migraine interventions.BackgroundAdhesive dermally applied microarray (ADAM) is an investigational system for intracutaneous drug administration. The recently completed pivotal Phase 2b/3 study (ZOTRIP), evaluating ADAM zolmitriptan for the treatment of acute moderate to severe migraine, was one of the first large studies to incorporate MBS freedom and pain freedom as co-primary endpoints per recently issued guidance by the US Food and Drug Administration. In this trial, the proportion of patients treated with ADAM zolmitriptan 3.8 mg, who were pain-free and MBS-free at 2 hours post-dose, was significantly higher than for placebo.MethodsWe undertook a post-hoc analysis of data from the ZOTRIP trial to examine how the outcomes from this trial compare to what might have been achieved using the conventional co-primary endpoints of pain relief, nausea, photophobia, and phonophobia.ResultsOf the 159 patients treated with ADAM zolmitriptan 3.8 mg or placebo, prospectively designated MBS were photophobia (n = 79), phonophobia (n = 43), and nausea (n = 37). Two-hour pain free rates in those with photophobia as the MBS were 36% for ADAM zolmitriptan 3.8 mg and 14% for placebo (P = .02). Corresponding rates for those with phonophobia as the MBS were 14% and 41% (P = .05). For those whose MBS was nausea, corresponding values were 56% and 16%, respectively (P = .01). Two-hour freedom from the MBS for active drug vs placebo were 67% vs 35% (P < .01) for photophobia, 55% vs 43% (P = .45) for phonophobia, and 89% vs 58% for nausea (P = .04). MBS freedom but not pain freedom was achieved in 28%. Only 1 patient (1%) achieved pain freedom, but not MBS freedom. The proportion with both pain and MBS freedom was highest (56%) among those whose MBS was nausea.ConclusionIn this study, the use of MBS was feasible and seemed to compare favorably to the previously required 4 co-primary endpoints
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